Benign Obstetric History in Women with Sickle-cell Anaemia Associated with -Thalassaemia
نویسندگان
چکیده
منابع مشابه
Sickle-cell anaemia, sickle-cell thalassaemia, sickle-cell haemoglobin C disease, and asymptomatic haemoglobin C thalassaemia in one Ghanaian family.
A Ghanaian family is described in which a sickle-cell haemoglobin C man married to a sickle-cell thalassaemia woman produced 12 children (eight alive). Four children have sickle-cell anaemia, two sickle-cell haemoglobin C disease, one has sickle-cell thalassaemia, and one is asymptomatic haemoglobin C thalassaemia.It is emphasized that the contribution that adult sickle-cell disease patients ma...
متن کاملIncidence of Sickle Cell Anaemia and Thalassaemia in Central India
Haemoglobinopathies are group of diseases characterized by abnormalities both quantitative and qualitative in the synthesis of haemoglobin. Haemoglobinopathies consist of sickle cell anaemia (SCA), thalassaemia (β) and variant haemoglobins. In India, they are responsible for the largest number of genetic disorders and hence are of great public health hazardous. In India major concerned haemoglo...
متن کاملBeta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability.
Thalassaemia and sickle cell disease (SCD) represent the most common forms of hereditary haemolytic anaemia and result from a partial or complete lack of synthesis of one of the major alpha- or beta-globin chains of haemoglobin A or from a single amino acid mutation (beta(6Glu-->Val)) of the beta-globin chain respectively. Although they have different pathophysiologies, patients with these cond...
متن کاملHepatopulmonary syndrome associated with iron overload in sickle cell anaemia.
At present, it is estimated that 10,000 to 20,000 patients in the USA are treated with long-term blood transfusion [1], including patients with sickle cell disease (SCD) who are often transfused to prevent stroke [2, 3]. Iron overload is common in patients with recurrent transfusion, and the degree of iron overload may correlate with the rate of transfusions [4, 5]. While iron overload and cirr...
متن کاملAssociation of BCL11A genetic variant (rs11886868) with severity in β-thalassaemia major & sickle cell anaemia
BACKGROUND & OBJECTIVES The amount of foetal haemoglobin that persists in adulthood affects the clinical severity of haemoglobinopathies including β-thalassaemia major and sickle cell anaemia (SCA). The present study was undertaken to analyse β-thalassaemia as well as SCA patients for the single nucleotide polymorphism (SNP), rs11886868 (T/C) in BCL11A gene and to evaluate the association betwe...
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ژورنال
عنوان ژورنال: BMJ
سال: 1972
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5839.524